<html>
<head>
<meta http-equiv=Content-Type content="text/html; charset=us-ascii">
<meta name=Generator content="Microsoft Word 11 (filtered)">
<style>
<!--
/* Font Definitions */
@font-face
{font-family:Wingdings;
panose-1:5 0 0 0 0 0 0 0 0 0;}
@font-face
{font-family:"Tempus Sans ITC";
panose-1:4 2 4 4 3 13 7 2 2 2;}
@font-face
{font-family:Default;
panose-1:0 0 0 0 0 0 0 0 0 0;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0pt;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Times New Roman";}
a:link, span.MsoHyperlink
{color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{color:purple;
text-decoration:underline;}
p
{margin-right:0pt;
margin-left:0pt;
font-size:12.0pt;
font-family:"Times New Roman";}
span.EmailStyle17
{font-family:Arial;
color:windowtext;}
@page Section1
{size:612.0pt 792.0pt;
margin:72.0pt 90.0pt 72.0pt 90.0pt;}
div.Section1
{page:Section1;}
/* List Definitions */
ol
{margin-bottom:0pt;}
ul
{margin-bottom:0pt;}
-->
</style>
</head>
<body lang=EN-US link=blue vlink=purple>
<div class=Section1>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'>RE: EVENTS - Natural
Health Products & Ingredients 2006 [WASHINGTON DC METRO AREA]</span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'> </span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'>On behalf of the respective Program
Planning Committees, enclosed please find information on <b><span
style='font-weight:bold'>TWO EVENTS</span></b> <b><i><span style='font-weight:
bold;font-style:italic'>that may be of interest to your Members, Colleagues
and/or Readership:</span></i></b></span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'> </span></font></p>
<ul style='margin-top:0pt' type=disc>
<li class=MsoNormal style='color:blue'><b><font size=2 color=blue face=Arial><span
style='font-size:10.0pt;font-family:Arial;font-weight:bold'>ASP-FDA
Workshop on Botanicals as “New” Drugs - Sat, Aug 5, 2006</span></font></b><font
size=2 face=Arial><span style='font-size:10.0pt;font-family:Arial'>
[Crystal-Gateway Marriott, Arlington, VA] </span></font></li>
</ul>
<p class=MsoNormal style='margin-left:54.0pt'><font size=2 color=blue
face=Arial><span style='font-size:10.0pt;font-family:Arial;color:blue'> </span></font></p>
<ul style='margin-top:0pt' type=disc>
<li class=MsoNormal style='color:blue'><b><font size=2 color=blue face=Arial><span
style='font-size:10.0pt;font-family:Arial;font-weight:bold'>DIA-ISAPP
First International Conference on Probiotics as Foods and Drugs –
Scientific and Regulatory Challenges – October 16-17, 2006 </span></font></b></li>
</ul>
<p class=MsoNormal style='text-indent:36.0pt'><font size=2 color=blue
face=Arial><span style='font-size:10.0pt;font-family:Arial;color:blue'>[University
of Maryland Conference Center, College Park Campus] </span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'> </span></font></p>
<p class=MsoNormal><b><font size=2 color=black face=Arial><span
style='font-size:10.0pt;font-family:Arial;color:black;font-weight:bold'>See
information below, and Attached Flyers. </span></font></b></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'> </span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'>We hope you will POST and DISSEMINATE
this information. </span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'> </span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'>Should you have questions, please do not
hesitate to contact the <b><span style='font-weight:bold'>Sponsoring
organizations</span></b> (see flyers, or below). Or you may contact me
directly at the numbers below. </span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'> </span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'>Thanking you in advance, </span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'> </span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'>Dr. Freddie Ann Hoffman</span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'>--- Conference Chair </span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'> </span></font></p>
<p class=MsoNormal><font size=2 color=black face=Arial><span style='font-size:
10.0pt;font-family:Arial;color:black'> </span></font></p>
<p style='margin:0pt;margin-bottom:.0001pt'><font size=2 color=black
face="Times New Roman"><span style='font-size:10.0pt;color:black'>Freddie Ann
Hoffman, MD</span></font><font color=black><span style='color:black'> <br>
</span></font><b><font size=5 color=blue face="Tempus Sans ITC"><span
style='font-size:16.0pt;font-family:"Tempus Sans ITC";color:blue;font-weight:
bold'>H</span></font></b><b><font color=blue face="Tempus Sans ITC"><span
style='font-family:"Tempus Sans ITC";color:blue;font-weight:bold'>eteroGeneity,
LLC</span></font></b><font color=blue><span style='color:blue'> </span></font><font
color=black><span style='color:black'><br>
</span></font><font size=2 color=black><span style='font-size:10.0pt;
color:black'>5611 16th Street, NW</span></font><font color=black><span
style='color:black'> <br>
</span></font><font size=2 color=black><span style='font-size:10.0pt;
color:black'>Washington</span></font><font size=2 color=black><span
style='font-size:10.0pt;color:black'>, DC 20011-6809</span></font><font
color=black><span style='color:black'> <br>
</span></font><font size=2 color=black><span style='font-size:10.0pt;
color:black'>Tel.: 202-545-6843 </span></font></p>
<p style='margin:0pt;margin-bottom:.0001pt'><font size=2 color=black
face="Times New Roman"><span style='font-size:10.0pt;color:black'>Mobile:
202-294-5819</span></font><font color=black><span style='color:black'> <br>
</span></font><font size=2 color=black><span style='font-size:10.0pt;
color:black'>Fax: 202-545-6844</span></font><font color=black><span
style='color:black'> <br>
</span></font><u><font size=2 color=black><span style='font-size:10.0pt;
color:black'><a href="mailto:fhoffman@heterogeneity-LLC.com"><font color=black><span
style='color:black'>fhoffman@heterogeneity-LLC.com</span></font></a></span></font></u></p>
<p style='margin:0pt;margin-bottom:.0001pt'><font size=2 color=black
face="Times New Roman"><span style='font-size:10.0pt;color:black'><a
href="http://www.heterogeneity-LLC.com"><font color=black><span
style='color:black'>www.heterogeneity-LLC.com</span></font></a></span></font></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=4
face="Times New Roman"><span style='font-size:14.0pt;font-weight:bold'>The
American Society of Pharmacognosy </span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><i><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold;
font-style:italic'>Is proud to present:</span></font></i></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=5
face="Times New Roman"><span style='font-size:18.0pt;font-weight:bold'>A
Workshop: Botanicals as “New” Drugs </span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><font size=3
face="Times New Roman"><span style='font-size:12.0pt'>Co-Sponsored by the</span></font></p>
<p class=MsoNormal align=center style='text-align:center'><b><i><font size=4
face="Times New Roman"><span style='font-size:14.0pt;font-weight:bold;
font-style:italic'>Center for Drug Evaluation and Research,</span></font></i></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><i><font size=4
face="Times New Roman"><span style='font-size:14.0pt;font-weight:bold;
font-style:italic'>Food and Drug Administration</span></font></i></b></p>
<p class=MsoNormal align=center style='text-align:center'><font size=3
color=black face=Arial><span style='font-size:12.0pt;font-family:Arial;
color:black'><img border=0 width=85 height=42
src="cid:image002.jpg@01C67B76.766CD880" alt="FDA logo" align=top></span></font></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=5
face="Times New Roman"><span style='font-size:16.0pt;font-weight:bold'>Saturday,
August 5, 2006</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=5
face="Times New Roman"><span style='font-size:16.0pt;font-weight:bold'> </span></font>(11
AM – 4PM)</b></p>
<p class=MsoNormal align=center style='text-align:center'><font size=3
face="Times New Roman"><span style='font-size:12.0pt'> </span></font></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=4
face="Times New Roman"><span style='font-size:14.0pt;font-weight:bold'>Crystal
Gateway Marriott - Arlington, Virginia </span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><font size=2
face="Times New Roman"><span style='font-size:10.0pt'>
(just across the Potomac River from Washington, D.C.)</span></font></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=4
face="Times New Roman"><span style='font-size:14.0pt;font-weight:bold'> </span></font></b></p>
<p align=center style='margin:0pt;margin-bottom:.0001pt;text-align:center'><font
size=3 face="Times New Roman"><span style='font-size:12.0pt'>In conjunction
with </span></font></p>
<p align=center style='margin:0pt;margin-bottom:.0001pt;text-align:center'><b><font
size=4 face="Times New Roman"><span style='font-size:14.0pt;font-weight:bold'>The
47th Annual Meeting of the American Society of Pharmacognosy</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=2
face="Times New Roman"><span style='font-size:11.0pt;font-weight:bold'>Aug 6 -
9, 2006</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><font size=2
face="Courier New"><span style='font-size:10.0pt;font-family:"Courier New"'> </span></font></p>
<p class=MsoNormal align=center style='text-align:center'><font size=2
face="Courier New"><span style='font-size:10.0pt;font-family:"Courier New"'> </span></font></p>
<p class=MsoNormal><u><font size=3 face="Times New Roman"><span
style='font-size:12.0pt'>COURSE DESCRIPTION</span></font></u>: This
Workshop is an introduction to the drug development process for <b><span
style='font-weight:bold'>naturally complex or heterogeneous products</span></b>,
such as botanicals. Experts in the field will address the current status
of USA drug development for botanical drugs. Learn how to select a
product for development as a “drug.” Learn what FDA is
looking for in the Chemistry, Manufacturing, and Controls (CMC) and
Pharmacology-Toxicology sections of an Investigational New Drug (IND) application
for a Botanical Drug. </p>
<p class=MsoNormal><font size=3 face="Times New Roman"><span style='font-size:
12.0pt'> </span></font></p>
<p class=MsoNormal style='margin-right:0pt;margin-bottom:6.0pt;margin-left:
0pt;text-indent:0pt'><font size=2 face=Symbol><span style='font-size:10.0pt;
font-family:Symbol'>·<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></font><i><span style='font-style:italic'>How does FDA
define “botanical?” </span></i></p>
<p class=MsoNormal style='margin-right:0pt;margin-bottom:6.0pt;margin-left:
18.0pt;text-indent:-18.0pt'><font size=2 face=Symbol><span style='font-size:
10.0pt;font-family:Symbol'>·<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></font><i><span style='font-style:italic'>When should a
botanical be developed as a “drug”? </span></i></p>
<p class=MsoNormal style='margin-right:0pt;margin-bottom:6.0pt;margin-left:
18.0pt;text-indent:-18.0pt'><font size=2 face=Symbol><span style='font-size:
10.0pt;font-family:Symbol'>·<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></font><i><span style='font-style:italic'>What are the
differences between botanical “foods” and botanical
“drugs”? </span></i></p>
<p class=MsoNormal style='margin-right:0pt;margin-bottom:6.0pt;margin-left:
18.0pt;text-indent:-18.0pt'><font size=2 face=Symbol><span style='font-size:
10.0pt;font-family:Symbol'>·<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></font><i><span style='font-style:italic'>What kinds of marketing
claims can be made for botanical drugs? </span></i></p>
<p class=MsoNormal style='margin-right:0pt;margin-bottom:6.0pt;margin-left:
18.0pt;text-indent:-18.0pt'><font size=2 face=Symbol><span style='font-size:
10.0pt;font-family:Symbol'>·<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></font><i><span style='font-style:italic'>When should an
Investigational New Drug (IND) application be filed with FDA?</span></i></p>
<p class=MsoNormal style='margin-right:0pt;margin-bottom:6.0pt;margin-left:
18.0pt;text-indent:-18.0pt'><font size=2 face=Symbol><span style='font-size:
10.0pt;font-family:Symbol'>·<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></font><i><span style='font-style:italic'>How does the FDA
process and review Botanical INDs and New Drug Applications (NDAs)?</span></i></p>
<p class=MsoNormal style='margin-right:0pt;margin-bottom:6.0pt;margin-left:
18.0pt;text-indent:-18.0pt'><font size=2 face=Symbol><span style='font-size:
10.0pt;font-family:Symbol'>·<font size=1 face="Times New Roman"><span
style='font:7.0pt "Times New Roman"'>
</span></font></span></font><i><span style='font-style:italic'>What are the
pertinent FDA regulations, policies and individuals you should know about for
botanical drug development? </span></i></p>
<p class=MsoNormal><u><font size=3 face="Times New Roman"><span
style='font-size:12.0pt'><br>
WHO SHOULD ATTEND:</span></font></u> Ingredient
Manufacturers, Suppliers, Directors of Research and Development, Researchers,
Academicians, Potential Drug Sponsors, Medicinal & Natural Products
Chemists, Pharmacologists, Toxicologists, Botanists, GMP Specialists, Clinical
Investigators, Clinical Trials Specialists, Policy-makers. </p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=purple face="Times New Roman"><span style='font-size:12.0pt;color:purple;
font-weight:bold'>WORKSHOP REGISTRATION:</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=purple face="Times New Roman"><span style='font-size:12.0pt;color:purple;
font-weight:bold'>$295 – Workshop Only [Sat. Aug.
5] $25 - ASP
Attendees</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><i><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-style:italic'>TO
REGISTER—OR For more information please see:</span></font></i></p>
<p class=MsoNormal align=center style='text-align:center'><i><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-style:italic'> </span></font></i><b><span
style='font-weight:bold'>The American Society for Pharmacognosy</span></b></p>
<p class=MsoNormal align=center style='text-align:center'><u><font size=4
face="Times New Roman"><span style='font-size:14.0pt'> <b><span
style='font-weight:bold'><a
href="http://www.phcog.org/AnnualMtg/Washington.html"><font color=navy><span
style='color:windowtext'>www.phcog.org/AnnualMtg/Washington.html</span></font></a></span></b></span></font></u></p>
<p class=MsoNormal align=center style='text-align:center'><i><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-style:italic'> </span></font></i></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold'>Contact:
Dr. Tawnya McKee, ASP Conference Organizer</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold'>(e-mail:
<font color=purple><span style='color:purple'> </span></font></span><font
color=purple><span style='color:purple'><a href="mailto:mckee@ncifcrf.gov"><font
color=purple><span style='color:purple;text-decoration:none'>mckee@ncifcrf.gov</span></font></a></span></font>
)</font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold'>Dr.
Freddie Ann Hoffman, Workshop Organizer</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold'>(e-mail:
<font color=purple><span style='color:purple'><a
href="mailto:Fhoffman@heterogeneity-LLC.com"><font color=purple><span
style='color:purple;text-decoration:none'>Fhoffman@heterogeneity-LLC.com</span></font></a>)</span></font></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
face="Times New Roman"><span style='font-size:12.0pt;font-weight:bold'>202-545-6843</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><font size=3
color=blue face=Default><span style='font-size:12.0pt;font-family:Default;
color:blue'>_____________________________________________________</span></font><font
color=black face=Default><span style='font-family:Default;color:black'>_</span></font></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=black face=Default><span style='font-size:12.0pt;font-family:Default;
color:black;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=black face=Default><span style='font-size:12.0pt;font-family:Default;
color:black;font-weight:bold'>Natural Health Products Special Interest Area
Community</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=4
color=black face=Default><span style='font-size:14.0pt;font-family:Default;
color:black;font-weight:bold'>Drug Information Association (DIA) </span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=black face=Default><span style='font-size:12.0pt;font-family:Default;
color:black;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><i><font size=3
color=black face=Default><span style='font-size:12.0pt;font-family:Default;
color:black;font-weight:bold;font-style:italic'>in conjunction with the<br>
</span></font></i></b><b><font size=4 color=purple face=Default><span
style='font-size:14.0pt;font-family:Default;color:purple;font-weight:bold'>International
Scientific Association for Probiotics & Prebiotics </span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><i><font size=3
color=black face=Default><span style='font-size:12.0pt;font-family:Default;
color:black;font-weight:bold;font-style:italic'>present: </span></font></i></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=black face=Default><span style='font-size:12.0pt;font-family:Default;
color:black;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color="#3300cc" face=Default><span style='font-size:12.0pt;font-family:Default;
color:#3300CC;font-weight:bold'>The First DIA International Conference on </span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=5
color="#3300cc" face=Default><span style='font-size:16.0pt;font-family:Default;
color:#3300CC;font-weight:bold'>PROBIOTICS AS FOODS & AS DRUGS -<br>
SCIENTIFIC & REGULATORY CHALLENGES</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=4
color=blue face=Default><span style='font-size:13.5pt;font-family:Default;
color:blue;font-weight:bold'>16 -17 October 2006</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=black face=Default><span style='font-size:12.0pt;font-family:Default;
color:black;font-weight:bold'>University</span></font></b><b><font
color=black face=Default><span style='font-family:Default;color:black;
font-weight:bold'> of Maryland Conference Center <br>
College Park, Maryland</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=black face=Default><span style='font-size:12.0pt;font-family:Default;
color:black;font-weight:bold'>Chairs: </span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font
size=3 color=black face=Default><span style='font-size:12.0pt;font-family:
Default;color:black;font-weight:bold'>Patricia Hibberd</span></font></b><b><font
color=black face=Default><span style='font-family:Default;color:black;
font-weight:bold'>, MD, PhD - <i><span style='font-style:italic'>Tufts</span></i><i><span
style='font-style:italic'> New England Medical Center</span></i><br>
James Heimbach, PhD - <i><span style='font-style:italic'>JHeimbach, LLC<br>
</span></i>Freddie Ann Hoffman, MD - <i><span style='font-style:italic'>HeteroGeneity,
LLC</span></i></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=black face=Default><span style='font-size:12.0pt;font-family:Default;
color:black;font-weight:bold'>[Continuing Education Credits]</span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color="#3300cc" face=Default><span style='font-size:12.0pt;font-family:Default;
color:#3300CC;font-weight:bold'>Contact: Drug Information
Association (215-442-6100)<br>
<a href="http://www.diahome.org/">www.diahome.org</a></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><font size=3
face="Times New Roman"><span style='font-size:12.0pt'> </span></font></p>
</div>
</body>
</html>