<html>
<head>
<meta http-equiv=Content-Type content="text/html; charset=us-ascii">
<meta name=Generator content="Microsoft Word 11 (filtered)">
<style>
<!--
/* Font Definitions */
@font-face
{font-family:"Tempus Sans ITC";
panose-1:4 2 4 4 3 13 7 2 2 2;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0pt;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Times New Roman";}
a:link, span.MsoHyperlink
{color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{color:purple;
text-decoration:underline;}
p
{margin-right:0pt;
margin-left:0pt;
font-size:12.0pt;
font-family:"Times New Roman";}
span.EmailStyle17
{font-family:Arial;
color:windowtext;}
@page Section1
{size:612.0pt 792.0pt;
margin:72.0pt 90.0pt 72.0pt 90.0pt;}
div.Section1
{page:Section1;}
-->
</style>
</head>
<body lang=EN-US link=blue vlink=purple>
<div class=Section1>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>To the Botanical Community: </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>RE: For further distribution</span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>It is with deepest sorrow that I post the announcement of
the passing of Dr. Floyd E. Leaders, Jr. Floyd was a
monumental figure in the research and drug development of botanical products in
the United States. He was a mentor and colleague, and most
importantly--a friend. </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>A brief biographical sketch is below (and attached).</span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>Most sincerely, </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> </span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>Freddie Ann Hoffman, MD</span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'>_________________________________________________</span></font></p>
<p class=MsoNormal><font size=2 face=Arial><span style='font-size:10.0pt;
font-family:Arial'> </span></font></p>
<p style='margin:0pt;margin-bottom:.0001pt'><font size=2 color=navy
face="Times New Roman"><span style='font-size:10.0pt;color:navy'>Freddie Ann
Hoffman, MD</span></font><font color=navy><span style='color:navy'> <br>
</span></font><b><font size=5 color=navy face="Tempus Sans ITC"><span
style='font-size:16.0pt;font-family:"Tempus Sans ITC";color:navy;font-weight:
bold'>H</span></font></b><b><font color=navy face="Tempus Sans ITC"><span
style='font-family:"Tempus Sans ITC";color:navy;font-weight:bold'>eteroGeneity,
LLC</span></font></b><font color=navy><span style='color:navy'> <br>
</span></font><font size=2 color=navy><span style='font-size:10.0pt;color:navy'>5611
16th Street, NW</span></font><font color=navy><span style='color:navy'> <br>
</span></font><font size=2 color=navy><span style='font-size:10.0pt;
color:navy'>Washington</span></font><font size=2 color=navy><span
style='font-size:10.0pt;color:navy'>, DC 20011</span></font><font
color=navy><span style='color:navy'> <br>
</span></font><font size=2 color=navy><span style='font-size:10.0pt;color:navy'>Tel.:
202-545-6843</span></font><font color=navy><span style='color:navy'> <br>
</span></font><font size=2 color=navy><span style='font-size:10.0pt;color:navy'>Fax:
202-545-6844</span></font><font color=navy><span style='color:navy'> <br>
</span></font><u><font size=2 color=navy><span style='font-size:10.0pt;
color:navy'><a href="mailto:fhoffman@heterogeneity-LLC.com"><font color=navy><span
style='color:navy'>fhoffman@heterogeneity-LLC.com</span></font></a></span></font></u></p>
<p style='margin:0pt;margin-bottom:.0001pt'><font size=2 color=navy
face="Times New Roman"><span style='font-size:10.0pt;color:navy'><a
href="http://www.heterogeneity-LLC.com"><font color=navy><span
style='color:navy'>www.heterogeneity-LLC.com</span></font></a></span></font></p>
<p class=MsoNormal align=center style='text-align:center'><font size=3
face="Times New Roman"><span style='font-size:12.0pt'> </span></font></p>
<p class=MsoNormal align=center style='text-align:center'><font size=3
face="Times New Roman"><span style='font-size:12.0pt'> </span></font></p>
<p class=MsoNormal align=center style='text-align:center'><b><font size=3
color=purple face="Times New Roman"><span style='font-size:12.0pt;color:purple;
font-weight:bold'>FLOYD E. LEADERS, JR, PHD</span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'>Dr. Leaders received a
Bachelors of Science in Pharmacy from Drake University in 1955. He
went on to receive a Masters of Science in Pharmacology, and later a Doctorate
in Pharmacology from the State University of Iowa in 1962. His first
professional position was as an assistant professor of pharmacology at the University of Kansas Medical School in Kansas City. In 1967 he left academia to
join Alcon Laboratories (Fort Worth, TX), and he continued to move up through
the ranks of the pharmaceutical industry, serving as Director of Research
Services at Schering-Plough, and then Director of R & D at Pennwalt
Corporation. By 1977, Dr. Leaders had founded Technical Evaluation
and Management Services, Inc., a Dallas-based contract research organizations,
one of the first CROs to run clinical trials for the pharmaceutical industry to
meet the FDA’s regulatory standards. </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'>In the early
1990’s he also formed his own consultancy group, The Leaders Group, Inc.,
from which he served as consultant to the newly established Office of
Alternative Medicine at the National Institutes of Health. In this role,
he assisted researchers, clinical investigators, federal agencies and the
industry to understand not only the need for carefully designed studies and
data management, but also the rigorous requirements for US drug development and approval. Through his patience and powerful negotiation
skills, Dr. Leaders was successful in assisting sponsors in filing
Investigational New Drug applications for heterogeneous botanical products with
the FDA Center for Drug Evaluation and Research. He also co-chaired
more than a half dozen workshops on botanical drug development, sponsored by
the Drug Information Association, the Food and Drug Administration, and the
National Institutes of Health. </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'>An outgrowth of his work
with both federal and private sector colleagues was the development of the
scientific underpinnings for the FDA CDER Guidance document on Botanical
Drugs. In 1997, Dr. Leaders formed yet another entity - Botanical
Enterprises, Inc. (BEI), located in Rockville, Maryland. As Chairman and
CEO, he entered into commercial agreements with potential companies and drug
sponsors with the purpose of developing botanical drug products. </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'>Following a protracted
illness, Dr. Floyd Leaders passed away on February 26, 2006. He is
survived by his wife, Madeline van Hoose, and his daughter. </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'> </span></font></b></p>
<p><b><font size=3 color=purple face="Times New Roman"><span style='font-size:
12.0pt;color:purple;font-weight:bold'> </span></font></b></p>
<p class=MsoNormal><b><font size=3 color=purple face="Times New Roman"><span
style='font-size:12.0pt;color:purple;font-weight:bold'> </span></font></b></p>
</div>
</body>
</html>